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KMID : 0383820140760010030
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Tuberculosis and Respiratory Diseases
2014 Volume.76 No. 1 p.30 ~ p.33
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The First Korean Case of Nontuberculous Mycobacterial Lung Disease Caused by Mycobacterium abscessus Subspecies bolletii in a Patient with Bronchiectasis
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Jeong Byeong-Ho
Kim Su-Young
Jeon Kyeong-Man
Huh Hee-Jae
Ki Chang-Seok
Lee Nam-Yong
Shin Sung-Jae
Koh Won-Jung
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Abstract
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We report the first Korean case of lung diseases caused by Mycobacterium abscessus subsp. bolletii in a previously healthy male, except for a previous history of pulmonary tuberculosis and bronchiectasis. All serial isolates are identified as M. abscessus subsp. bolletii by multi-locus sequence analysis based on the hsp65, rpoB, and 16S rRNA fragments. At the genetic level, the isolate has the erm(41) gene with a T28 sequevar, associated with clarithromycin resistance, and no rrl mutation. The isolate is resistant to clarithromycin. Although the symptoms and radiographic findings have improved after combination of antibiotics, the follow-up sputum cultures are persistently positive.
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KEYWORD
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Bronchiectasis, Mycobacterium Infections, Nontuberculous, Nontuberculous Mycobacteria, Sequence Analysis, DNA
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